Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.67 |
| ▸ | AURKA | O14965 | 10/20 | 0.67 |
| ▸ | TEK | Q02763 | 10/20 | 0.67 |
| ▸ | MET | P08581 | 9/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.67 |
| ▸ | LCK | P06239 | 7/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.54 |
| ▸ | LYN | P07948 | 3/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | PDXK | O00764 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774867 | 0.81 | KDR (0.83) | KDRAURKATEKMETAURKB | |
| SCHEMBL5773976 | 0.81 | KDR (0.76) | KDRAURKATEKMETAURKB | |
| SCHEMBL2747562 | 0.80 | KDR (1.00) | KDRAURKATEKMETAURKB | |
| SCHEMBL22540530 | 0.80 | KDR (0.62) | KDRAURKATEKMETAURKB | |
| SCHEMBL22048385 | 0.79 | KDR (0.67) | KDRAURKATEKMETAURKB | |
| SCHEMBL22540525 | 0.79 | KDR (0.74) | KDRAURKATEKMETAURKB | |
| SCHEMBL22048737 | 0.78 | KDR (0.64) | KDRAURKATEKMETAURKB | |
| SCHEMBL382398 | 0.78 | KDR (0.87) | KDRAURKATEKMETAURKB | |
| SCHEMBL29258970 | 0.76 | KDR (0.85) | KDRAURKATEKMETAURKB | |
| SCHEMBL2746955 | 0.75 | KDR (0.82) | KDRAURKATEKMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014113616-A1 | PROCESS FOR PREPARING THE ANTI-TUMOR AGENT 6-(7-((1-AMINOCYCLOPROPYL) METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND ITS CRYSTALLINE | Advenchen Pharmaceuticals, LLC (US) | 2014-07-24 | — | — | WO | disclosed |