Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.76 |
| ▸ | AURKA | O14965 | 11/20 | 0.76 |
| ▸ | TEK | Q02763 | 11/20 | 0.76 |
| ▸ | MET | P08581 | 10/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.76 |
| ▸ | LCK | P06239 | 8/20 | 0.76 |
| ▸ | FLT1 | P17948 | 3/20 | 0.62 |
| ▸ | LYN | P07948 | 3/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.62 |
| ▸ | PDXK | O00764 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.62 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774867 | 0.90 | KDR (0.83) | KDRAURKATEKMETAURKB | |
| SCHEMBL6316909 | 0.87 | KDR (0.64) | KDRAURKATEKMETAURKB | |
| SCHEMBL2747562 | 0.87 | KDR (1.00) | KDRAURKATEKMETAURKB | |
| SCHEMBL382398 | 0.86 | KDR (0.87) | KDRAURKATEKMETAURKB | |
| SCHEMBL5771547 | 0.86 | KDR (0.70) | KDRAURKATEKMETAURKB | |
| SCHEMBL29258970 | 0.82 | KDR (0.85) | KDRAURKATEKMETAURKB | |
| SCHEMBL2746955 | 0.81 | KDR (0.82) | KDRAURKATEKMETAURKB | |
| SCHEMBL15895415 | 0.81 | KDR (0.67) | KDRAURKATEKMETAURKB | |
| SCHEMBL2100341 | 0.81 | KDR (0.83) | KDRAURKATEKMETAURKB | |
| SCHEMBL5772575 | 0.80 | FGFR1 (0.67) | KDRAURKATEKMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660503-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050070508-A1 | Napthalene carboxamides and their derivatives useful as new anti-angiogenic agents | AGOURON PHARMACEUTICALS, INC. | 2005-03-31 | — | — | US | disclosed |
| WO-2005021553-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070508-A1 | Napthalene carboxamides and their derivatives useful as new anti-angiogenic agents | CCNA1, CCNA2, CCNT1 | KDR 30/4885AURKA 2306/4885TEK 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.