Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.56 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232791 | 0.88 | HSD11B1 (0.72) | HSD11B1HSD11B2SMN1; SMN2LMNAMEN1 | |
| SCHEMBL15899712 | 0.87 | HSD11B1 (0.44) | HSD11B1HSD11B2SMN1; SMN2LMNA | |
| SCHEMBL15899879 | 0.86 | HSD11B1 (0.54) | HSD11B1HSD11B2 | |
| SCHEMBL15899907 | 0.85 | HSD11B1 (0.77) | HSD11B1HSD11B2 | |
| SCHEMBL15899935 | 0.84 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL15899783 | 0.81 | HSD11B1 (0.58) | HSD11B1HSD11B2 | |
| SCHEMBL15899760 | 0.81 | HSD11B1 (0.51) | HSD11B1HSD11B2GAA | |
| SCHEMBL15899906 | 0.80 | HSD11B1 (0.53) | HSD11B1HSD11B2LMNAALDH1A1HTT | |
| SCHEMBL15899731 | 0.80 | HSD11B1 (0.50) | HSD11B1HSD11B2 | |
| SCHEMBL15899928 | 0.80 | HSD11B1 (0.48) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751108-B1 | ADAMANTYL-ACETAMIDE DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBVIE INC (US) | 2014-07-30 | — | — | EP | claimed |