Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 3/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.33 |
| ▸ | PRKCA | P17252 | 4/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15899927 | 0.88 | PIK3CD (0.41) | PIK3CDSOS1DYRK1APIK3CAPIK3CB | |
| SCHEMBL14481217 | 0.86 | SOS1 (0.42) | PIK3CDSOS1DYRK1APIK3CAPIK3CB | |
| SCHEMBL14481214 | 0.86 | SOS1 (0.42) | PIK3CDSOS1DYRK1APIK3CAPIK3CB | |
| SCHEMBL15327034 | 0.85 | TNF (0.38) | PIK3CDSOS1KRAS | |
| SCHEMBL17530857 | 0.81 | IDH1 (0.34) | PIK3CDSOS1PIK3CALRRK2PRMT5 | |
| SCHEMBL17530862 | 0.81 | SOS1 (0.34) | PIK3CDSOS1LRRK2 | |
| SCHEMBL17530773 | 0.77 | SOS1 (0.34) | SOS1KRAS | |
| SCHEMBL14481021 | 0.76 | PIK3CD (0.41) | PIK3CDSOS1DYRK1APIK3CAPIK3CB | |
| SCHEMBL14481023 | 0.76 | PIK3CD (0.41) | PIK3CDSOS1DYRK1APIK3CAPIK3CB | |
| SCHEMBL15899984 | 0.74 | PIK3CD (0.46) | PIK3CDSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499129-B1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-07-30 | — | — | EP | claimed |