SCHEMBL15899863

SCHEMBL15899863

CC(C)(C(=O)NC1C2CC3CC1CC(OC(=O)O)(C3)C2)N1CCN(c2ccc(F)cc2F)CC1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 20/20 0.46
HSD11B2 P80365 8/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15899912 0.92 HSD11B1 (0.49) HSD11B1HSD11B2
SCHEMBL15899864 0.91 HSD11B1 (0.49) HSD11B1HSD11B2
SCHEMBL15899789 0.89 HSD11B1 (0.47) HSD11B1HSD11B2
SCHEMBL15899908 0.89 HSD11B1 (0.43) HSD11B1HSD11B2
SCHEMBL15899716 0.87 HSD11B1 (0.49) HSD11B1HSD11B2
SCHEMBL231241 0.86 HSD11B1 (0.61) HSD11B1HSD11B2
SCHEMBL15899748 0.85 HSD11B1 (0.42) HSD11B1HSD11B2
SCHEMBL15899866 0.85 HSD11B1 (0.45) HSD11B1HSD11B2
SCHEMBL15899718 0.84 HSD11B1 (0.44) HSD11B1HSD11B2
SCHEMBL3949752 0.84 HSD11B1 (0.44) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1751108-B1 ADAMANTYL-ACETAMIDE DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME ABBVIE INC (US) 2014-07-30 EP claimed