SCHEMBL15901646

SCHEMBL15901646

O=C(Nc1cc[nH]c(=O)c1)c1cc(C(F)(F)F)ccc1F

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 20/20 0.72
SCN8A Q9UQD0 19/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15901692 0.90 SCN10A (0.66) SCN10ASCN8A
SCHEMBL15901652 0.90 SCN10A (0.69) SCN10ASCN8A
Bromide SCHEMBL16777889 0.89 SCN10A (0.68) SCN10ASCN8A
SCHEMBL15561960 0.85 SCN10A (1.00) SCN10ASCN8A
SCHEMBL15901791 0.84 SCN8A (0.65) SCN10ASCN8A
SCHEMBL28064011 0.83 SCN8A (0.69) SCN10ASCN8A
SCHEMBL15902433 0.83 SCN8A (1.00) SCN10ASCN8A
SCHEMBL15902052 0.83 SCN8A (0.69) SCN10ASCN8A
SCHEMBL28822369 0.82 ESR1 (0.65) SCN10ASCN8A
SCHEMBL15901817 0.82 SCN8A (1.00) SCN10ASCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3459958-B1 PROCESS AND INTERMEDIATES FOR PREPARING PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMA (US) 2024-08-07 EP disclosed
US-11773119-B2 Prodrugs of pyridone amides useful as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-10-03 US disclosed
US-11673864-B2 Pyridone amides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-06-13 US disclosed
US-11673864-B2 Pyridone amides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-06-13 US disclosed
EP-3865475-A1 PROCESS FOR PREPARING PYRIDONE AMIDES WHICH ARE MODULATORS OF SODIUM CHANNELS AND INTERMEDIATE COMPOUNDS USED THEREIN Vertex Pharmaceuticals Incorporated (US) 2021-08-18 EP disclosed
EP-3865475-A1 PROCESS FOR PREPARING PYRIDONE AMIDES WHICH ARE MODULATORS OF SODIUM CHANNELS AND INTERMEDIATE COMPOUNDS USED THEREIN Vertex Pharmaceuticals Incorporated (US) 2021-08-18 EP disclosed
CN-108395452-B Prodrugs of pyridone amides as sodium channel modulators 沃泰克斯药物股份有限公司 2021-08-03 CN disclosed
CN-108164457-B Pyridone amides as sodium channel modulators 沃泰克斯药物股份有限公司 2021-07-09 CN disclosed
US-20210047271-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS (SAN DIEGO) LLC 2021-02-18 US disclosed
US-20210047271-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS (SAN DIEGO) LLC 2021-02-18 US disclosed
WO-2015089361-A1 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2015-06-18 WO disclosed
US-20150166589-A1 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) 2015-06-18 US disclosed
US-9051270-B2 Pyridone amides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2015-06-09 US disclosed
US-9051270-B2 Pyridone amides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2015-06-09 US disclosed
WO-2014120808-A9 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PARMACEUTICALS INCORPORATED (US) 2015-05-14 WO disclosed
WO-2014120808-A9 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PARMACEUTICALS INCORPORATED (US) 2015-05-14 WO disclosed
WO-2014120808-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PARMACEUTICALS INCORPORATED (US) 2014-08-07 WO disclosed
WO-2014120808-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PARMACEUTICALS INCORPORATED (US) 2014-08-07 WO disclosed
US-20140213616-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2014-07-31 US disclosed
US-20140213616-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2014-07-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140213616-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS SCN5A, SCN1A, KCNJ2 SCN10A 12/4885SCN8A 77/4885
US-20150166589-A1 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS TRPV1, P2RY1, P2RX3 SCN10A 32/4885SCN8A 70/4885
US-11773119-B2 Prodrugs of pyridone amides useful as modulators of sodium channels TRPV1, P2RY1, P2RX3 SCN10A 32/4885SCN8A 70/4885
US-20210047271-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS SCN5A, SCN1A, KCNJ2 SCN10A 12/4885SCN8A 77/4885
US-11673864-B2 Pyridone amides as modulators of sodium channels SCN5A, SCN1A, KCNJ2 SCN10A 12/4885SCN8A 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.