Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892578 | 0.90 | MAPK14 (0.45) | MAPK14ALDH1A1GAAL3MBTL1POLQ | |
| SCHEMBL15903436 | 0.89 | HTT (0.48) | MAPK14ALDH1A1GAAL3MBTL1POLQ | |
| SCHEMBL15903063 | 0.87 | MAPK14 (0.40) | MAPK14GAAPOLQOPRM1OPRL1 | |
| SCHEMBL15903204 | 0.84 | MAPK14 (0.41) | MAPK14ALDH1A1GAAL3MBTL1POLQ | |
| SCHEMBL18825315 | 0.82 | HTT (0.40) | MAPK14GAAPOLQOPRM1OPRL1 | |
| SCHEMBL17894004 | 0.81 | MAPK14 (0.41) | MAPK14ALDH1A1GAAL3MBTL1POLQ | |
| SCHEMBL15903268 | 0.78 | MAPK14 (0.39) | MAPK14POLQOPRM1OPRL1HTT | |
| SCHEMBL15903361 | 0.74 | ALDH1A1 (0.41) | MAPK14ALDH1A1GAAOPRM1OPRL1 | |
| SCHEMBL15903091 | 0.73 | GLA (0.41) | MAPK14GAAPOLQOPRM1OPRL1 | |
| SCHEMBL17894096 | 0.73 | ALDH1A1 (0.36) | MAPK14ALDH1A1GAAL3MBTL1POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948458-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-02 | — | — | EP | claimed |
| WO-2014114185-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-07-31 | — | — | WO | claimed |
| EP-2948458-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014114185-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-07-31 | — | — | WO | disclosed |