Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590559 | 1.00 | NR4A1 (0.40) | NR4A1NR4A2NR4A3PLK1ALDH1A1 | |
| SCHEMBL12702465 | 1.00 | NR4A1 (0.40) | NR4A1NR4A2NR4A3PLK1ALDH1A1 | |
| SCHEMBL1590558 | 1.00 | NR4A1 (0.40) | NR4A1NR4A2NR4A3PLK1ALDH1A1 | |
| SCHEMBL30258129 | 0.79 | RXFP1 (0.36) | KMT2AMEN1CNR2HTTNPC1 | |
| SCHEMBL30890559 | 0.79 | KMT2A (0.53) | ALDH1A1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL18383195 | 0.79 | KMT2A (0.53) | ALDH1A1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL17007007 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKMT2AHTTNPC1 | |
| SCHEMBL18097129 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKMT2AHTTNPC1 | |
| SCHEMBL568601 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKMT2AHTTNPC1 | |
| SCHEMBL20616524 | 0.78 | GPR3 (0.39) | ALDH1A1HPGDKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092468-A1 | Pharmaceutical Calcimimetics | CONCERT PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | US | disclosed |
| US-20080261926-A1 | Pharmaceutical Calcimimetics | CONCERT PHARMACEUTICALS INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092468-A1 | Pharmaceutical Calcimimetics | CASR, CALCR, PTH1R | NR4A1 850/4885NR4A2 576/4885NR4A3 529/4885 |
| US-20080261926-A1 | Pharmaceutical Calcimimetics | CASR, CALCR, PTH1R | NR4A1 850/4885NR4A2 576/4885NR4A3 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.