⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788841 | 1.00 | — | — | |
| SCHEMBL16674740 | 0.88 | INPP5A (0.34) | — | |
| SCHEMBL15492644 | 0.87 | — | — | |
| SCHEMBL18119005 | 0.87 | — | — | |
| SCHEMBL15806353 | 0.87 | — | — | |
| SCHEMBL16674741 | 0.87 | — | — | |
| SCHEMBL10018595 | 0.87 | — | — | |
| SCHEMBL14626368 | 0.87 | — | — | |
| SCHEMBL10005833 | 0.87 | — | — | |
| SCHEMBL18119006 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150011001-A1 | COMPOSITIONS AND METHODS FOR OPTIMIZING CLEAVAGE OF RNA BY RNASE H | ISIS PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8790919-B2 | Compositions and methods for optimizing cleavage of RNA by RNase H | ISIS PHARMACEUTICALS, INC. (US) | 2014-07-29 | — | — | US | disclosed |