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Sugi Predict / Targets / INPP5A

INPP5A

Inositol polyphosphate-5-phosphatase A · Q14642 · INPP5A on Sugi Atlas →

4,315 patent compounds predicted against INPP5A, 2,308 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4186085 SCHEMBL4186085 1.00 6/20
SCHEMBL130697 SCHEMBL130697 0.71 6/20
SCHEMBL4186925 SCHEMBL4186925 0.71 6/20
SCHEMBL4454764 SCHEMBL4454764 0.71 6/20
SCHEMBL2573126 SCHEMBL2573126 0.70 6/20
SCHEMBL329313 SCHEMBL329313 0.68 6/20
SCHEMBL3727874 SCHEMBL3727874 0.64 6/20
SCHEMBL4671842 SCHEMBL4671842 0.61 6/20
SCHEMBL4181314 SCHEMBL4181314 0.60 6/20
SCHEMBL522291 SCHEMBL522291 0.59 6/20
SCHEMBL582185 SCHEMBL582185 0.59 6/20
SCHEMBL4172258 SCHEMBL4172258 0.59 6/20
SCHEMBL842250 SCHEMBL842250 0.59 6/20
SCHEMBL2851716 SCHEMBL2851716 0.59 6/20
SCHEMBL2472745 SCHEMBL2472745 0.57 6/20
SCHEMBL3727743 SCHEMBL3727743 0.57 6/20
SCHEMBL131227 SCHEMBL131227 0.56 6/20
SCHEMBL3093492 SCHEMBL3093492 0.56 6/20
SCHEMBL61616 SCHEMBL61616 0.54 6/20
SCHEMBL1641458 SCHEMBL1641458 0.54 6/20

Clinical trials — most relevant to INPP5A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Alendronate Versus Denosumab in Kidney Transplant Patients PHASE2/PHASE3COMPLETED
Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients PHASE3COMPLETED
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC) PHASE2COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Evaluation of Safety, Tolerability, and Efficacy of INZ-701 in Adults With ENPP1 Deficiency PHASE1/PHASE2COMPLETED
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease. PHASE1COMPLETED
Pappalysin 2 (PAPP-A2) Enzyme Replacement PHASE1COMPLETED
The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency PHASE1RECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Exome Sequencing for Atypical Femoral Fractures nanCOMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies nanCOMPLETED
Studying Phosphorus Metabolism nanCOMPLETED
Biomarker for Hypophosphatasia Disease (BioHypophos) nanWITHDRAWN
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism nanNOT_YET_RECRUITING
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans nanUNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers nanCOMPLETED
Prognostic Value of Protein IMP3 Expression in Cervical Cancer nanCOMPLETED
IP3R Modulation by Cancer Genes in Mesothelioma nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Hypophosphatemic Rickets in Norway nanUNKNOWN
Targeted Next Generation Sequencing and Intellectual Disability nanCOMPLETED
Study of Constitutional Platelet Disease nanUNKNOWN
TSH Receptor Mutations Among a Consanguineous Community nanCOMPLETED
Bone Density and Vascular Calcifications Evolution After Renal Transplant nanRECRUITING
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers nanCOMPLETED
Molecular and Immunohistochemical Profiling of Tumors in Patients With Parathyroid Tumors nanRECRUITING
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity. nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a INPP5A binder may also engage these)

ProteinNameSimilarity
Q7TNC9 — 1.000 Q7TNC9 →
Q29467 — 1.000 Q29467 →
D3ZZX1 — 1.000 D3ZZX1 →
Q96LI5 — 0.950 Q96LI5 →
Q8VEG6 — 0.943 Q8VEG6 →
A7YWS7 — 0.924 A7YWS7 →
Q5RB35 — 0.923 Q5RB35 →
O89050 — 0.922 O89050 →
Q9UL63 — 0.922 Q9UL63 →
CDC16 Cell division cycle protein 16 homolog 0.922 landscape →
P51583 — 0.921 P51583 →
Q9JIB4 — 0.921 Q9JIB4 →
Q6UXG2 — 0.921 Q6UXG2 →
Q99PV3 — 0.920 Q99PV3 →
Q7SXR3 — 0.920 Q7SXR3 →
Q5VU57 — 0.919 Q5VU57 →
PAICS Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase 0.919 landscape →
Q96DM3 — 0.919 Q96DM3 →
Q02353 — 0.918 Q02353 →
Q6GR10 — 0.918 Q6GR10 →
Q5RB59 — 0.918 Q5RB59 →
E2R222 — 0.917 E2R222 →
Q5ZKQ6 — 0.917 Q5ZKQ6 →
Q5XHZ9 — 0.917 Q5XHZ9 →
Q9DCL9 — 0.917 Q9DCL9 →
A0JN27 — 0.917 A0JN27 →
P52848 — 0.916 P52848 →
Q5R532 — 0.916 Q5R532 →
Q99LD4 — 0.916 Q99LD4 →
A7MB76 — 0.916 A7MB76 →