Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906127 | 0.98 | PDE4B (0.47) | PDE4BL3MBTL1HRH3ACHEKMT2A | |
| SCHEMBL3790844 | 0.87 | PDE4B (0.47) | PDE4BL3MBTL1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL15906095 | 0.86 | KMT2A (0.46) | PDE4BKMT2AHCRTR1HCRTR2 | |
| SCHEMBL3786400 | 0.86 | L3MBTL1 (0.53) | PDE4BL3MBTL1ACHEKMT2AADRA1D | |
| SCHEMBL8064986 | 0.86 | PDE4B (0.44) | PDE4BL3MBTL1HRH3ACHEKMT2A | |
| SCHEMBL3792406 | 0.86 | PDE4B (0.62) | PDE4BL3MBTL1HRH3KMT2AHCRTR1 | |
| SCHEMBL3790892 | 0.84 | MAPK1 (0.44) | PDE4BL3MBTL1ACHEKMT2A | |
| SCHEMBL3789371 | 0.84 | PDE4B (0.44) | PDE4BL3MBTL1HRH3ACHEKMT2A | |
| SCHEMBL8060160 | 0.84 | PDE4B (0.44) | PDE4BL3MBTL1HRH3ACHEKMT2A | |
| SCHEMBL7918270 | 0.84 | PDE4B (0.44) | PDE4BL3MBTL1KMT2AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | disclosed |
| US-8791267-B2 | Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | PDE4B 2/4885L3MBTL1 3346/4885HRH3 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.