Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906141 | 0.88 | MAPT (0.46) | MAPTPDE4BADORA2ALMNAGAA | |
| SCHEMBL15906190 | 0.85 | PDE4D (0.42) | MAPTPDE4BLMNATP53HPGD | |
| SCHEMBL8066667 | 0.85 | PDE4D (0.42) | PDE4BADORA2APDE4D | |
| SCHEMBL15906155 | 0.85 | MAPT (0.46) | MAPTPDE4BLMNAGAATHRB | |
| SCHEMBL15906132 | 0.85 | PDE4B (0.43) | MAPTPDE4BLMNATP53POLB | |
| SCHEMBL4328873 | 0.85 | TUBB4A (0.45) | MAPTPDE4BGAAPOLBTUBB4A | |
| SCHEMBL15906143 | 0.84 | CYP11B1 (0.43) | MAPTPDE4BADORA2ALMNATP53 | |
| SCHEMBL16302099 | 0.84 | MAPT (0.42) | MAPTPDE4BPOLBTUBB4ATUBB | |
| SCHEMBL15906171 | 0.78 | CNR1 (0.41) | MAPTLMNAGAATP53HPGD | |
| SCHEMBL15906145 | 0.77 | MAPT (0.46) | MAPTPDE4BLMNATP53TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791267-B2 | Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-07-29 | — | — | US | disclosed |