Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | CTSA | P10619 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906102 | 0.86 | PDE4B (0.49) | PDE4BPDE4DCTSASMN1; SMN2KDM4E | |
| SCHEMBL15906187 | 0.86 | PDE4B (0.49) | PDE4BPDE4DCTSASMN1; SMN2KDM4E | |
| SCHEMBL15906105 | 0.82 | DRD4 (0.43) | PDE4BPDE4DCTSASMN1; SMN2KDM4E | |
| SCHEMBL16158623 | 0.81 | PDE4B (0.46) | PDE4BPDE4D | |
| SCHEMBL15906152 | 0.80 | HSD17B10 (0.50) | CTSASMN1; SMN2KDM4ENPC1TSHR | |
| SCHEMBL15906151 | 0.80 | PDE4B (0.76) | PDE4BPDE4D | |
| SCHEMBL15906150 | 0.79 | PDE4B (0.60) | PDE4BPDE4D | |
| SCHEMBL3795591 | 0.79 | PDE4B (0.71) | PDE4BPDE4DSMN1; SMN2RAB9A | |
| SCHEMBL15906103 | 0.74 | NLRP3 (0.46) | PDE4BPDE4DCTSA | |
| SCHEMBL14500803 | 0.71 | PSMB5 (0.45) | CTSASMN1; SMN2KDM4ENPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791267-B2 | Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-07-29 | — | — | US | disclosed |