Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.42 |
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906236 | 0.87 | ALDH1A1 (0.44) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL14652176 | 0.85 | SMN1; SMN2 (0.39) | CNR2EPHX1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL15906233 | 0.84 | EPHX1 (0.38) | EPHX1ALDH1A1NPC1RAB9ASSTR4 | |
| SCHEMBL15906245 | 0.74 | EPHX1 (0.47) | EPHX1GAASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14655013 | 0.72 | EPHX1 (0.46) | EPHX1GAASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL15906238 | 0.72 | EPHX1 (0.46) | EPHX1GAASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14652181 | 0.72 | ALDH1A1 (0.41) | ALDH1A1SSTR4 | |
| SCHEMBL15906201 | 0.71 | EPHX1 (0.52) | EPHX1GAASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL16900168 | 0.71 | EGFR (0.42) | CNR1CNR2EPHX1GAASMN1; SMN2 | |
| SCHEMBL13563754 | 0.71 | EGFR (0.42) | CNR1CNR2EPHX1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791257-B2 | Substituted pyrrolotriazines as protein kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-29 | — | — | US | disclosed |