⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16385966 | 0.87 | — | — | |
| SCHEMBL10126291 | 0.83 | — | — | |
| SCHEMBL705463 | 0.81 | DUT (0.32) | — | |
| SCHEMBL15906205 | 0.76 | — | — | |
| SCHEMBL13433828 | 0.74 | SMYD2 (0.32) | — | |
| SCHEMBL13722428 | 0.73 | SMYD2 (0.30) | — | |
| SCHEMBL15468491 | 0.70 | SMYD2 (0.34) | — | |
| SCHEMBL705315 | 0.69 | P2RY6 (0.37) | — | |
| SCHEMBL13433829 | 0.68 | — | — | |
| SCHEMBL6887827 | 0.68 | SMYD2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357856-A1 | CHIMERIC OLIGOMERIC COMPOUNDS COMPRISING ALTERNATING REGIONS OF NORTHERN AND SOUTHERN CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2014-12-04 | — | — | US | disclosed |
| US-8791083-B2 | Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry | ISIS PHARMACEUTICALS, INC. (US) | 2014-07-29 | — | — | US | disclosed |