Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.36 |
| ▸ | PDE4A | P27815 | 8/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758625 | 0.78 | PDE10A (0.52) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL1758627 | 0.74 | PDE10A (0.49) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL1758462 | 0.74 | SMN1; SMN2 (0.39) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL1758543 | 0.73 | PDE10A (0.58) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL6872912 | 0.72 | PDE10A (0.51) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL10413532 | 0.61 | MAPK14 (0.59) | — | |
| SCHEMBL1758612 | 0.61 | SLC6A3 (0.72) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL1758598 | 0.59 | PDE10A (0.53) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL3269566 | 0.59 | PDE10A (0.58) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL188012 | 0.59 | PDE10A (0.63) | PDE10APDE4BPDE4APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493513-B1 | RADIOLABELLED PDE10 LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-30 | — | — | EP | disclosed |