Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 13/20 | 0.45 |
| ▸ | IGF1R | P08069 | 8/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2797385 | 0.84 | TNK2 (0.52) | TNK2IGF1R | |
| SCHEMBL3648444 | 0.84 | PDE1C (0.33) | TNK2 | |
| SCHEMBL401216 | 0.84 | TNK2 (0.58) | TNK2IGF1RINSREGFRCYP3A4 | |
| SCHEMBL10226172 | 0.84 | TNK2 (0.58) | TNK2IGF1RINSREGFRCYP3A4 | |
| SCHEMBL4541532 | 0.84 | TNK2 (0.58) | TNK2IGF1RINSREGFRCYP3A4 | |
| SCHEMBL15052317 | 0.79 | TNK2 (0.33) | TNK2 | |
| SCHEMBL400530 | 0.78 | TNK2 (0.45) | TNK2IGF1RCYP3A4 | |
| SCHEMBL3641428 | 0.78 | TNK2 (0.36) | TNK2 | |
| SCHEMBL1567075 | 0.76 | TNK2 (0.53) | TNK2IGF1RFGFR1 | |
| SCHEMBL401909 | 0.75 | TNK2 (0.59) | TNK2IGF1RINSREGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796455-B2 | Fused bicyclic mTOR inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-08-05 | — | — | US | disclosed |