Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13386210 | 0.86 | BCHE (0.42) | NR1H2NR1H3BCHEMAPTSMN1; SMN2 | |
| SCHEMBL13386133 | 0.83 | BCHE (0.40) | NR1H2NR1H3BCHEMAPTSMN1; SMN2 | |
| SCHEMBL13386285 | 0.80 | BCHE (0.39) | NR1H2NR1H3BCHEMAPTSMN1; SMN2 | |
| SCHEMBL13386281 | 0.79 | PIK3CA (0.41) | BCHEMAPTSMN1; SMN2LMNAGPR119 | |
| SCHEMBL13386122 | 0.79 | BCHE (0.39) | BCHESMN1; SMN2LMNATSHRGPR119 | |
| SCHEMBL15908923 | 0.76 | BCHE (0.46) | NR1H2NR1H3BCHESMN1; SMN2USP30 | |
| SCHEMBL2594780 | 0.74 | PDK2 (0.46) | BCHEMAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL2585068 | 0.72 | SIRT6 (0.41) | BCHEMAPTKDM4EHTTCSF1R | |
| SCHEMBL21196734 | 0.71 | BCHE (0.41) | NR1H2NR1H3BCHEMAPTSMN1; SMN2 | |
| SCHEMBL9933040 | 0.70 | BCHE (0.40) | BCHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170151253-A1 | Compounds, Compositions, and Methods for Treating Alzheimer's Disease | Prosetta Antiviral, Inc. | 2017-06-01 | — | — | US | disclosed |
| US-20170151253-A1 | Compounds, Compositions, and Methods for Treating Alzheimer's Disease | Prosetta Antiviral, Inc. | 2017-06-01 | — | — | US | disclosed |
| US-20170151253-A1 | Compounds, Compositions, and Methods for Treating Alzheimer's Disease | Prosetta Antiviral, Inc. | 2017-06-01 | — | — | US | disclosed |
| US-9382221-B2 | Compounds, compositions, and methods for treating alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382221-B2 | Compounds, compositions, and methods for treating alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382221-B2 | Compounds, compositions, and methods for treating alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140315897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE | Prosetta Antiviral, Inc. | 2014-10-23 | — | — | US | disclosed |
| US-20140315897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE | Prosetta Antiviral, Inc. | 2014-10-23 | — | — | US | disclosed |
| US-20140315897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE | Prosetta Antiviral, Inc. | 2014-10-23 | — | — | US | disclosed |
| US-8796448-B1 | Compounds, compositions, and methods for treating Alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796448-B1 | Compounds, compositions, and methods for treating Alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796448-B1 | Compounds, compositions, and methods for treating Alzheimer's disease | PROSETTA ANTIVIRAL INC. (US) | 2014-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170151253-A1 | Compounds, Compositions, and Methods for Treating Alzheimer's Disease | PSEN1, APP, PSEN2 | NR1H2 1969/4885NR1H3 2336/4885BCHE 12/4885 |
| US-20140315897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE | PSEN1, APP, PSEN2 | NR1H2 1969/4885NR1H3 2336/4885BCHE 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.