Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478358 | 0.89 | RAB9A (0.85) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL14061846 | 0.83 | NPC1 (0.97) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL4419275 | 0.79 | NPC1 (0.74) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL6468865 | 0.79 | RAB9A (0.60) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL31375520 | 0.79 | RAB9A (0.60) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL12188551 | 0.76 | NPC1 (0.85) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL27035104 | 0.74 | SIRT2 (0.60) | RAB9ANPC1L3MBTL1LMNAHTT | |
| SCHEMBL13416897 | 0.74 | GAA (0.73) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL25338113 | 0.73 | CA12 (0.66) | RAB9ANPC1L3MBTL1MAOAMAOB | |
| SCHEMBL21889825 | 0.73 | CA12 (0.61) | RAB9ANPC1L3MBTL1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3243385-B1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3243385-A1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | Merck Sharp & Dohme Corp. (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2677869-B1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2017-11-08 | — | — | EP | disclosed |
| US-8796258-B2 | Cyclic azabenzimidazole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2014-08-05 | — | — | US | disclosed |