Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12589524 | 1.00 | RIPK1 (0.49) | RIPK1NOD2NOD1MAPTMEN1 | |
| SCHEMBL1976785 | 0.97 | RIPK1 (0.50) | RIPK1NOD2NOD1MAPTMEN1 | |
| SCHEMBL12589489 | 0.90 | RIPK1 (0.49) | RIPK1MAPT | |
| SCHEMBL1977282 | 0.89 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL15911360 | 0.89 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL12589565 | 0.88 | RIPK1 (0.51) | RIPK1RAB9A | |
| SCHEMBL1977295 | 0.88 | RIPK1 (0.48) | RIPK1NPC1RAB9A | |
| SCHEMBL12589527 | 0.88 | RIPK1 (0.52) | RIPK1NPC1RAB9A | |
| SCHEMBL12589526 | 0.88 | RIPK1 (0.48) | RIPK1NPC1RAB9A | |
| SCHEMBL12589563 | 0.88 | RIPK1 (0.48) | RIPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509981-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | LILLY CO ELI (US) | 2014-08-06 | — | — | EP | disclosed |