SCHEMBL15914419

SCHEMBL15914419

COc1ccc(-c2nc3ccc(-c4cc(C#N)cs4)cn3c2CCN2CCCN(C)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 12/20 0.41
▸ CHKA P35790 1/20 0.39
▸ KCNK3 O14649 1/20 0.38
▸ KCNK9 Q9NPC2 1/20 0.38
▸ SLC2A2 P11168 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ PTBP1 P26599 1/20 0.35
▸ HTR7 P34969 1/20 0.35
▸ MTNR1A P48039 2/20 0.35
▸ MTNR1B P49286 2/20 0.35
▸ TSPO P30536 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819409 0.93 SLC2A1 (0.49) SLC2A1CHKAKCNK3KCNK9KDM4E
SCHEMBL15914178 0.93 SLC2A1 (0.41) SLC2A1CHKAKCNK3KCNK9SLC2A2
SCHEMBL15914887 0.89 SLC2A1 (0.43) SLC2A1KCNK3KCNK9SLC2A2KDM4E
SCHEMBL15914576 0.88 SLC2A1 (0.49) SLC2A1CHKAKCNK3KCNK9SLC2A2
SCHEMBL15914748 0.88 SLC2A1 (0.49) SLC2A1CHKAKCNK3KCNK9SLC2A2
SCHEMBL15914562 0.86 SLC2A1 (0.43) SLC2A1CHKAKCNK3KCNK9SLC2A2
SCHEMBL15914902 0.85 SLC2A1 (0.42) SLC2A1CHKASLC2A2KDM4EHPGD
SCHEMBL12819045 0.85 SLC2A1 (0.50) SLC2A1CHKAKCNK3KCNK9SLC2A2
SCHEMBL12819038 0.83 SLC2A1 (0.59) SLC2A1SLC2A2KDM4E
SCHEMBL15914755 0.82 SLC2A1 (0.43) SLC2A1CHKASLC2A2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885CHKA 1602/4885KCNK3 2267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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