SCHEMBL159145

SCHEMBL159145

COc1cc(SC)ccc1C(=O)N1CCC(Cc2ccccc2)CC1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.72
CYP2C19 P33261 4/20 0.72
MAPK14 Q16539 4/20 0.72
GAA P10253 3/20 0.70
HPGD P15428 3/20 0.63
LMNA P02545 2/20 0.63
TSHR P16473 1/20 0.63
NPC1 O15118 2/20 0.61
RAB9A P51151 2/20 0.61
HTR2B P41595 2/20 0.57
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
GFER P55789 2/20 0.55
ALDH1A1 P00352 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
MAPT P10636 2/20 0.55
KDM4E B2RXH2 1/20 0.55
APOBEC3A P31941 1/20 0.53
APOBEC3G Q9HC16 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5823073 0.86 CYP2C9 (0.77) CYP2C9CYP2C19MAPK14NPC1HTR2B
SCHEMBL5820252 0.86 CYP2C9 (0.77) CYP2C9CYP2C19MAPK14HTR2BMEN1
SCHEMBL7234983 0.84 CYP2C9 (1.00) CYP2C9CYP2C19MAPK14GAALMNA
SCHEMBL5821507 0.82 CYP2C9 (0.71) CYP2C9CYP2C19MAPK14NPC1HTR2B
SCHEMBL1063428 0.78 MAPK14 (0.72) CYP2C9CYP2C19MAPK14NPC1HTR2B
SCHEMBL7604997 0.77 CYP2C9 (0.77) CYP2C9CYP2C19MAPK14GAAHTR2B
SCHEMBL7231606 0.77 CYP2C9 (0.69) CYP2C9CYP2C19MAPK14GAAHTR2B
SCHEMBL10720113 0.76 CYP2C9 (0.81) CYP2C9CYP2C19MAPK14LMNAHTR2B
SCHEMBL3492151 0.76 MAPK14 (0.68) CYP2C9CYP2C19MAPK14NPC1HTR2B
SCHEMBL3883491 0.75 MAPK14 (0.60) CYP2C9CYP2C19MAPK14TSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215397-A1 TWO-DIMENSIONAL CULTURE METHOD HAVING CLEAR CHEMICAL COMPOSITION FOR CULTURING THREE-DIMENSIONAL INTESTINAL ORGANOID-DERIVED INTESTINAL STEM CELL AGGREGATE KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2025-07-03 US claimed
CN-119698462-A Two-dimensional culture method with definite chemical composition for culturing three-dimensional intestinal organoid derived intestinal stem cell population 韩国生命工学研究院 2025-03-25 CN claimed
US-12145981-B2 Methods and compounds for the treatment or prevention of severe influenza Poolbeg Pharma (UK) Limited (GB) 2024-11-19 US claimed
US-12091719-B2 Compositions and methods for detecting viruses in a sample WASHINGTON UNIVERSITY (US) 2024-09-17 US claimed
EP-4416268-A1 METHODS FOR PRODUCING CARTILAGE AND BONES Murdoch Children's Research Institute (AU) 2024-08-21 EP claimed
CN-118355110-A Method for producing cartilage and bone 默多克儿童研究所 2024-07-16 CN claimed
WO-2024112170-A1 METHOD FOR NON-XENOGENEIC CULTURING OF INTESTINAL STEM CELLS ON SURFACE COATED WITH THIN FILM 한국생명공학연구원 2024-05-30 WO claimed
CN-116942832-A Novel anti-infective strategy for combined infection of influenza virus and staphylococcus aureus 归属疗法有限公司 2023-10-27 CN claimed
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION 2023-09-14 US claimed
WO-2023153737-A1 TWO-DIMENSIONAL CULTURE METHOD HAVING CLEAR CHEMICAL COMPOSITION FOR CULTURING THREE-DIMENSIONAL INTESTINAL ORGANOID-DERIVED INTESTINAL STEM CELL AGGREGATE 한국생명공학연구원 2023-08-17 WO claimed
WO-2023060322-A1 METHODS FOR PRODUCING CARTILAGE AND BONES MURDOCH CHILDREN'S RESEARCH INSTITUTE (AU) 2023-04-20 WO claimed
WO-2023039578-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION (US) 2023-03-16 WO claimed
US-20220275062-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SEVERE INFLUENZA ORPH PHARMA IP COMPANY LIMITED (GB) 2022-09-01 US claimed
US-11339207-B2 Methods and compounds for the treatment or prevention of severe influenza ORPH PHARMA IP COMPANY LIMITED (GB) 2022-05-24 US claimed
US-20220096590-A1 NOVEL-ANTI-INFECTIVE STRATEGY AGAINST INFLUENZA VIRUS AND S. AUREUS COINFECTIONS ATRIVA THERAPEUTICS GMBH (DE) 2022-03-31 US claimed
US-20160137982-A1 P38 MAPK INHIBITOR-CONTAINING MEDIUM AND METHOD FOR OSTEOGENIC DIFFERENTIATION TAMPEREEN YLIOPISTO (FI) 2016-05-19 US claimed
EP-2834349-B1 P38 MAPK INHIBITOR-CONTAINING MEDIUM AND METHOD FOR OSTEOGENIC DIFFERENTIATION TAMPEREEN YLIOPISTO (FI) 2016-04-20 EP claimed
EP-2834349-A1 P38 MAPK INHIBITOR-CONTAINING MEDIUM AND METHOD FOR OSTEOGENIC DIFFERENTIATION Tampereen Yliopisto (FI) 2015-02-11 EP claimed
WO-2014202837-A1 P38 MAPK INHIBITOR-CONTAINING MEDIUM AND METHOD FOR OSTEOGENIC DIFFERENTIATION TAMPEREEN YLIOPISTO (FI) 2014-12-24 WO claimed
WO-2014122298-A1 INTERLEUKIN-4 INHIBITORS FOR THE TREAMTENT OF NEUTROPENIA Universität Zürich (CH) 2014-08-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12145981-B2 Methods and compounds for the treatment or prevention of severe influenza CXCL10, MAPK10, CCL11 CYP2C9 4152/4885CYP2C19 3660/4885MAPK14 14/4885
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER TP53, CD4, MCL1 CYP2C9 4493/4885CYP2C19 4433/4885MAPK14 4032/4885
US-20220096590-A1 NOVEL-ANTI-INFECTIVE STRATEGY AGAINST INFLUENZA VIRUS AND S. AUREUS COINFECTIONS MAPK1, MAP2K1, MAP2K6 CYP2C9 3464/4885CYP2C19 2991/4885MAPK14 14/4885
US-20220275062-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SEVERE INFLUENZA CXCL10, MAPK10, CCL11 CYP2C9 4152/4885CYP2C19 3660/4885MAPK14 14/4885
US-11339207-B2 Methods and compounds for the treatment or prevention of severe influenza CXCL10, MAPK10, MAPK1 CYP2C9 4041/4885CYP2C19 3554/4885MAPK14 15/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.