⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860617 | 0.67 | — | — | |
| SCHEMBL9713267 | 0.62 | — | — | |
| SCHEMBL17043 | 0.60 | — | — | |
| SCHEMBL1722236 | 0.59 | — | — | |
| SCHEMBL7934241 | 0.59 | — | — | |
| SCHEMBL3528169 | 0.59 | — | — | |
| SCHEMBL2547201 | 0.59 | — | — | |
| SCHEMBL3727885 | 0.59 | — | — | |
| SCHEMBL17971012 | 0.56 | — | — | |
| SCHEMBL7934289 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087211-B2 | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2018-10-02 | — | — | US | claimed |
| US-20170051008-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2017-02-23 | — | — | US | claimed |
| EP-2155204-B1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RES TRIANGLE INST (US) | 2016-08-17 | — | — | EP | claimed |
| US-20110092473-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2011-04-21 | — | — | US | claimed |
| EP-2155204-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | Cook, Kevin M. (US) | 2010-02-24 | — | — | EP | claimed |
| WO-2008157460-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | COOK, KEVIN, M. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-0837874-A2 | NEUROACTIVE STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES | Cocensys, Inc. (US) | 1998-04-29 | — | — | EP | claimed |
| WO-1996040043-A2 | NEUROACTIVE STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES | COCENSYS, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| US-10087211-B2 | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2018-10-02 | — | — | US | disclosed |
| US-20170051008-A1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2017-02-23 | — | — | US | disclosed |
| US-9518080-B2 | Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2016-12-13 | — | — | US | disclosed |
| EP-2155204-B1 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES | RES TRIANGLE INST (US) | 2016-08-17 | — | — | EP | disclosed |
| CN-101309900-B | Substituted cycloalkene derivative | DAIICHI SANKYO CO LTD | 2015-04-22 | — | — | CN | disclosed |
| US-8575375-B2 | Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties | RESEARCH TRIANGLE INSTITUTE (US) | 2013-11-05 | — | — | US | disclosed |
| US-5925630-A | MODULATION OF BRAIN EXCITABILITY TO RELIEVE STRESS, ANXIETY, INSOMNIA AND MOOD DISORDERS | COCENSYS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0837874-A2 | NEUROACTIVE STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES | Cocensys, Inc. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996040043-A2 | NEUROACTIVE STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES | COCENSYS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-4364400-A | 1,3-OXATHIANE AND 1,3-OXATHIOLANE DERIVATIVES | FIRMENICH SA (CH) | 1982-12-21 | — | — | US | disclosed |
| US-4262030-A | 1,3-OXATHIANE AND 1,3-OXATHIOLANE DERIVATIVES | FIRMENICH SA (CH) | 1981-04-14 | — | — | US | disclosed |
| US-4220561-A | Oxathiane and oxathiolane derivatives as perfuming agents | FIRMENICH SA (CH) | 1980-09-02 | — | — | US | disclosed |