Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.61 |
| ▸ | FEN1 | P39748 | 18/20 | 0.61 |
| ▸ | GRM5 | P41594 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15923459 | 0.86 | FEN1 (0.66) | ALOX5APFEN1 | |
| SCHEMBL15917500 | 0.83 | ALOX5AP (0.69) | ALOX5APFEN1GRM5 | |
| SCHEMBL20627448 | 0.77 | ALOX5AP (0.73) | ALOX5APFEN1GRM5 | |
| SCHEMBL15912779 | 0.76 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL15912942 | 0.76 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL15930235 | 0.75 | FEN1 (0.79) | ALOX5APFEN1 | |
| SCHEMBL15915467 | 0.75 | FEN1 (0.60) | ALOX5APFEN1GRM5 | |
| SCHEMBL15913075 | 0.74 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL15912771 | 0.74 | FEN1 (1.00) | ALOX5APFEN1 | |
| SCHEMBL15915788 | 0.73 | FEN1 (1.00) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884878-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-06 | — | — | US | disclosed |
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
| US-20150259357-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-17 | — | — | US | disclosed |
| US-9079866-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| US-20140221311-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | ALOX5AP 95/4885FEN1 1/4885GRM5 2511/4885 |
| US-20150259357-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | ALOX5AP 80/4885FEN1 2/4885GRM5 2302/4885 |
| US-20140221311-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | ALOX5AP 80/4885FEN1 2/4885GRM5 2302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.