Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.70 |
| ▸ | RAB9A | P51151 | 10/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15917585 | 1.00 | NPC1 (0.70) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL16034594 | 0.91 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL16077670 | 0.91 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL12443184 | 0.89 | ALDH1A1 (0.74) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL685193 | 0.89 | MAPT (0.67) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1173942 | 0.88 | NPC1 (0.70) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1173944 | 0.88 | NPC1 (0.70) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL16034661 | 0.87 | NPC1 (0.65) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL16077674 | 0.87 | NPC1 (0.65) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL20299054 | 0.86 | NPC1 (0.78) | NPC1RAB9AMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221429-A1 | HETEROCYCLIC SCHIFF'S BASES AS NOVEL AND NEW ANTIGLYCATION AGENTS | AL-RESAYES SAUD IBRAHIM (SA) | 2014-08-07 | — | — | US | disclosed |