Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.64 |
| ▸ | AXL | P30530 | 6/20 | 0.64 |
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | KIT | P10721 | 3/20 | 0.64 |
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | MERTK | Q12866 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15918424 | 1.00 | MET (0.64) | METAXLKDRRETKIT | |
| SCHEMBL15917788 | 0.96 | MET (0.69) | METAXLKDRRETKIT | |
| SCHEMBL15918683 | 0.96 | MET (0.69) | METAXLKDRRETKIT | |
| SCHEMBL15918162 | 0.96 | HDAC2 (0.69) | METAXLKDRRETKIT | |
| SCHEMBL15917659 | 0.96 | HDAC2 (0.69) | METAXLKDRRETKIT | |
| SCHEMBL15917470 | 0.95 | HDAC2 (0.70) | METAXLKDRRETKIT | |
| SCHEMBL15917808 | 0.95 | HDAC2 (0.70) | METAXLKDRRETKIT | |
| SCHEMBL15918114 | 0.95 | HDAC2 (0.70) | METAXLKDRRETKIT | |
| SCHEMBL15917325 | 0.95 | HDAC2 (0.70) | METAXLKDRRETKIT | |
| SCHEMBL15918412 | 0.93 | MET (0.62) | METAXLKDRRETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2769976-B1 | HYDROXAMIC ACID COMPOUND CONTAINING QUINOLYL AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THIS COMPOUND AND USE THEREOF | BEIJING KONRUNS PHARMACEUTICAL CO LTD (CN) | 2017-08-02 | — | — | EP | claimed |
| US-9186318-B2 | Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof | BEIJING KONRUNS PHARMACEUTICAL CO., LTD (CN) | 2015-11-17 | — | — | US | claimed |
| EP-2769976-A1 | HYDROXAMIC ACID COMPOUND CONTAINING QUINOLYL AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THIS COMPOUND AND USE THEREOF | Beijing Konruns Pharmaceutical Co., Ltd. (CN) | 2014-08-27 | — | — | EP | claimed |
| US-20140221425-A1 | Quinolyl-containing Hydroxamic Acid Compound and Preparation Method Thereof, and Pharmaceutical Composition Containing This Compound and Use Thereof | BEIJING KONRUNS PHARMACEUTICAL CO., LTD. (CN) | 2014-08-07 | — | — | US | claimed |
| US-9186318-B2 | Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof | BEIJING KONRUNS PHARMACEUTICAL CO., LTD (CN) | 2015-11-17 | — | — | US | disclosed |
| EP-2769976-A1 | HYDROXAMIC ACID COMPOUND CONTAINING QUINOLYL AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THIS COMPOUND AND USE THEREOF | Beijing Konruns Pharmaceutical Co., Ltd. (CN) | 2014-08-27 | — | — | EP | disclosed |
| US-20140221425-A1 | Quinolyl-containing Hydroxamic Acid Compound and Preparation Method Thereof, and Pharmaceutical Composition Containing This Compound and Use Thereof | BEIJING KONRUNS PHARMACEUTICAL CO., LTD. (CN) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221425-A1 | Quinolyl-containing Hydroxamic Acid Compound and Preparation Method Thereof, and Pharmaceutical Composition Containing This Compound and Use Thereof | HDAC5, HDAC1, HDAC7 | MET 1782/4885AXL 2018/4885KDR 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.