Methopterine

Methopterine

SCHEMBL159228

CN(Cc1cnc2nc(N)nc(O)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPGS Q05932 3/20 0.86
DHFR P00374 3/20 0.86
KDM4E B2RXH2 1/20 0.86
TLR4 O00206 1/20 0.86
MEN1 O00255 1/20 0.86
ALDH1A1 P00352 1/20 0.86
LMNA P02545 1/20 0.86
TP53 P04637 1/20 0.86
TYMS P04818 1/20 0.86
GLA P06280 1/20 0.86
POLB P06746 1/20 0.86
HMGB1 P09429 1/20 0.86
MAPT P10636 1/20 0.86
FOLR2 P14207 1/20 0.86
FOLR1 P15328 1/20 0.86
HPGD P15428 1/20 0.86
ALOX15 P16050 1/20 0.86
ALOX12 P18054 1/20 0.86
GART P22102 1/20 0.86
APEX1 P27695 1/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methopterine SCHEMBL6907131 1.00 FPGS (0.86) FPGSDHFRKDM4ETLR4MEN1
Methopterine SCHEMBL10658766 0.99 FPGS (0.84) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL9736207 0.97 DHFR (0.92) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL2301949 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL3712 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL16013534 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL171251 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL20548444 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
Methotrexate SCHEMBL3711 0.92 DHFR (1.00) FPGSDHFRKDM4ETLR4MEN1
SCHEMBL13524540 0.92 DHFR (0.87) FPGSDHFRKDM4ETLR4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5455 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091124-A1 CLICK-TO-RELEASE ON PROTEINS AND PEPTIDES VALANX BIOTECH GMBH (AT) 2026-04-02 US claimed
EP-4701667-A1 TROP2 BINDERS AND CONJUGATES THEREOF Merck Sharp & Dohme LLC (US) 2026-03-04 EP claimed
EP-4603107-A1 BIOORTHOGONAL, ANILINIUM BASED CLEAVABLE TETRAZINES University of Copenhagen (DK) 2025-08-20 EP claimed
EP-4590342-A1 CLICK-TO-RELEASE ON PROTEINS AND PEPTIDES VALANX Biotech GmbH (AT) 2025-07-30 EP claimed
US-20250235567-A1 AGENTS FOR TREATMENT OF ENDOMETRIOSIS AND OTHER BENIGN GYNECOLOGICAL NEOPLASMS Universitat Zürich (CH) 2025-07-24 US claimed
WO-2025122699-A1 CDC7 INHIBITOR COMBINATIONAL THERAPY Lin Bioscience, Inc. (TW) 2025-06-12 WO claimed
US-20250172563-A1 MATERIALS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF CANCER UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2025-05-29 US claimed
US-20250090495-A1 CDC7 Inhibitor Combinational Therapy Lin Bioscience, Inc. (TW) 2025-03-20 US claimed
EP-4507784-A1 AGENTS FOR TREATMENT OF ENDOMETRIOSIS AND OTHER BENIGN GYNECOLOGICAL NEOPLASMS Universität Zürich (CH) 2025-02-19 EP claimed
WO-2024226410-A1 TROP2 BINDERS AND CONJUGATES THEREOF MERCK SHARP & DOHME LLC (US) 2024-10-31 WO claimed
EP-0855910-A1 CONJUGATES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA Merck & Co., Inc. (US) 1998-08-05 EP claimed
EP-0853483-A1 NOVEL PEPTIDES Merck & Co., Inc. (US) 1998-07-22 EP claimed
WO-1998018493-A2 CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER MERCK & CO., INC. (US) 1998-05-07 WO claimed
WO-1998010651-A1 CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER MERCK & CO., INC. (US) 1998-03-19 WO claimed
EP-0771209-A2 NOVEL PEPTIDES Merck & Co., Inc. (a New Jersey corp.) (US) 1997-05-07 EP claimed
WO-1997014416-A1 CONJUGATES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA MERCK & CO., INC. (US) 1997-04-24 WO claimed
WO-1997012624-A1 NOVEL PEPTIDES MERCK & CO., INC. (US) 1997-04-10 WO claimed
WO-1996000503-A1 NOVEL PEPTIDES MERCK & CO., INC. (US) 1996-01-11 WO claimed
EP-0225823-B1 PROCESS FOR THE PREPARATION OF PTERIDINE DERIVATIVES RHONE-POULENC SANTE (FR) 1990-01-31 EP claimed
US-4767859-A Process for the preparation of pteridine derivatives RHONE-POULENC SANTE (FR) 1988-08-30 US claimed