Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.83 |
| ▸ | CA1 | P00915 | 8/20 | 0.83 |
| ▸ | CA6 | P23280 | 3/20 | 0.83 |
| ▸ | CA4 | P22748 | 2/20 | 0.83 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 9/20 | 0.50 |
| ▸ | CA5A | P35218 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630011 | 0.91 | CA2 (1.00) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL344271 | 0.91 | CA2 (1.00) | CA2CA1CA6CA4PLCG1 | |
| Potassium SCHEMBL10415326 | 0.89 | CA2 (0.95) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL10415325 | 0.89 | CA2 (0.95) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL29557979 | 0.78 | CA1 (0.56) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL1800130 | 0.78 | CA1 (0.56) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL8480118 | 0.78 | CA2 (0.61) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL31370840 | 0.78 | CA2 (0.61) | CA2CA1CA6CA4PLCG1 | |
| SCHEMBL202947 | 0.75 | CA2 (0.70) | CA2CA1CA6CA4CA9 | |
| SCHEMBL10363500 | 0.75 | CA2 (0.63) | CA2CA1CA6CA4PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951170-A2 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |