SCHEMBL15924656

SCHEMBL15924656

Nc1ncc(-c2ccc(-c3ccccc3S(N)(=O)=O)cc2CF)cn1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 20/20 0.72
FEN1 P39748 20/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15932372 0.84 ALOX5AP (1.00) ALOX5APFEN1
Trifluoroacetic Acid SCHEMBL15917168 0.76 ALOX5AP (0.83) ALOX5APFEN1
SCHEMBL15924657 0.72 ALOX5AP (0.64) ALOX5APFEN1
SCHEMBL15932373 0.72 ALOX5AP (0.79) ALOX5APFEN1
SCHEMBL15917341 0.72 FEN1 (1.00) ALOX5APFEN1
SCHEMBL6237306 0.71 ALOX5AP (0.77) ALOX5APFEN1
SCHEMBL20538689 0.71 ALOX5AP (0.62) ALOX5APFEN1
SCHEMBL15932369 0.71 ALOX5AP (0.78) ALOX5APFEN1
SCHEMBL20627031 0.71 ALOX5AP (0.76) ALOX5APFEN1
SCHEMBL15917352 0.70 ALOX5AP (1.00) ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-A2 FLAP MODULATORS Janssen Pharmaceutica, N.V. (BE) 2015-12-09 EP claimed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO claimed