Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930178 | 0.89 | BRAF (0.63) | BRAF | |
| SCHEMBL3757667 | 0.85 | BRAF (0.59) | BRAF | |
| SCHEMBL15925259 | 0.82 | BRAF (0.69) | BRAF | |
| SCHEMBL12455757 | 0.80 | BRAF (0.52) | BRAF | |
| SCHEMBL9909763 | 0.79 | BRAF (0.53) | BRAF | |
| SCHEMBL15925263 | 0.79 | BRAF (0.60) | BRAFKMT2A | |
| SCHEMBL28707059 | 0.77 | BRAF (0.56) | BRAF | |
| SCHEMBL2931091 | 0.77 | BRAF (1.00) | BRAF | |
| SCHEMBL2937399 | 0.77 | BRAF (0.48) | BRAF | |
| SCHEMBL2935268 | 0.76 | BRAF (0.68) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |