Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ESRRA | P11474 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6523569 | 0.82 | AURKA (0.53) | BRAFKMT2AESRRA | |
| SCHEMBL9909765 | 0.81 | BRAF (0.57) | BRAF | |
| SCHEMBL2931466 | 0.80 | AURKA (0.60) | BRAFKMT2A | |
| SCHEMBL4457106 | 0.80 | BRAF (0.73) | BRAF | |
| SCHEMBL13610853 | 0.79 | BRAF (0.70) | BRAF | |
| SCHEMBL15925262 | 0.79 | BRAF (0.62) | BRAFKMT2A | |
| SCHEMBL12652443 | 0.78 | BRAF (0.64) | BRAF | |
| SCHEMBL4458209 | 0.78 | BRAF (0.78) | BRAF | |
| SCHEMBL14018120 | 0.77 | MET (0.64) | BRAF | |
| SCHEMBL13603322 | 0.76 | BRAF (0.62) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |