Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303824 | 1.00 | BRD4 (0.59) | BRD4PIK3CDPIK3CAMTOR | |
| SCHEMBL15925879 | 0.84 | BRD4 (0.73) | BRD4 | |
| SCHEMBL14756066 | 0.84 | BRD4 (0.84) | BRD4 | |
| SCHEMBL16738351 | 0.84 | BRD4 (0.84) | BRD4 | |
| SCHEMBL16303822 | 0.81 | BRD4 (0.49) | BRD4 | |
| SCHEMBL15925878 | 0.81 | BRD4 (0.49) | BRD4 | |
| SCHEMBL16306561 | 0.81 | BRD4 (0.46) | BRD4 | |
| SCHEMBL15926491 | 0.81 | BRD4 (0.46) | BRD4 | |
| SCHEMBL9974006 | 0.79 | BRD4 (0.54) | BRD4 | |
| SCHEMBL16303825 | 0.78 | BRD4 (0.45) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796261-B2 | Bromodomain inhibitors and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796261-B2 | Bromodomain inhibitors and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |