Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974798 | 0.84 | FDPS (0.50) | FDPSLCKKDRMAPK8MAPK9 | |
| SCHEMBL12411191 | 0.80 | FDPS (0.58) | FDPSMAPK14LCKKDRMAPK8 | |
| SCHEMBL12144621 | 0.80 | FDPS (0.58) | FDPSMAPK14LCKMAPK13MAPK12 | |
| SCHEMBL12143896 | 0.77 | MAPK14 (0.39) | FDPSMAPK14LCKMAPK13MAPK12 | |
| SCHEMBL14313604 | 0.76 | MAPK14 (0.54) | FDPSMAPK14LCKMAPK13MAPK12 | |
| SCHEMBL14288406 | 0.76 | MAPK14 (0.54) | FDPSMAPK14LCKMAPK13MAPK12 | |
| SCHEMBL14288431 | 0.76 | MAPK14 (0.54) | FDPSMAPK14LCKMAPK13MAPK12 | |
| SCHEMBL14288407 | 0.74 | MAPK14 (0.52) | MAPK14LCKMAPK13MAPK12MAPK11 | |
| SCHEMBL14320130 | 0.74 | MAPK14 (0.52) | MAPK14LCKMAPK13MAPK12MAPK11 | |
| SCHEMBL11012256 | 0.73 | FDPS (0.50) | FDPSLCKKDRMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300466-B1 | IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-08-06 | — | — | EP | disclosed |