Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.62 |
| ▸ | GAK | O14976 | 3/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | BUB1 | O43683 | 2/20 | 0.62 |
| ▸ | STK10 | O94804 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.62 |
| ▸ | FECH | P22830 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15928192 | 0.96 | EGFR (0.62) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL16212531 | 0.90 | EGFR (0.78) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL14862652 | 0.89 | FBP1 (0.76) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL19026906 | 0.89 | FBP1 (0.65) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL29577864 | 0.88 | EGFR (0.79) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL1507680 | 0.87 | EGFR (0.76) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL29615047 | 0.87 | EGFR (0.76) | EGFRERBB2GAKRIPK2BUB1 | |
| Hydrochloric Acid SCHEMBL642049 | 0.86 | EGFR (0.74) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL27369686 | 0.84 | EGFR (0.72) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL29578618 | 0.83 | EGFR (0.79) | EGFRERBB2GAKRIPK2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014117698-A1 | TRICYCLIC DERIVATIVE CONTAINING QUINAZOLINE STRUCTURE, PREPARATION METHOD AND USE THEREOF | 江苏奥赛康药业股份有限公司 (CN) | 2014-08-07 | — | — | WO | disclosed |