⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14814298 | 0.73 | — | — | |
| SCHEMBL1954869 | 0.72 | — | — | |
| SCHEMBL1593431 | 0.71 | — | — | |
| SCHEMBL11442542 | 0.69 | — | — | |
| SCHEMBL16399737 | 0.69 | — | — | |
| SCHEMBL23791897 | 0.67 | — | — | |
| SCHEMBL17783724 | 0.67 | — | — | |
| SCHEMBL974044 | 0.67 | — | — | |
| SCHEMBL16398058 | 0.67 | — | — | |
| SCHEMBL14126250 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 267 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117229205-A | Preparation method and pharmaceutical application of phenyl acrylamide RHbDD1 inhibitor | 中国医学科学院基础医学研究所 | 2023-12-15 | — | — | CN | claimed |
| EP-3442977-B1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORP (US) | 2023-06-28 | — | — | EP | claimed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | claimed |
| CN-111606887-B | Novel kinase inhibitor | 安徽中科拓苒药物科学研究有限公司 | 2023-03-17 | — | — | CN | claimed |
| US-20220143001-A1 | NOVEL PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-05-12 | — | — | US | claimed |
| CN-110520496-B | Crosslinkable pressure-sensitive adhesive mass | 德莎欧洲股份公司 | 2022-02-22 | — | — | CN | claimed |
| EP-3932913-A1 | NEW-TYPE PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-01-05 | — | — | EP | claimed |
| CN-109311889-B | Activin receptor-like kinase inhibitors | 缆图药品公司 | 2021-11-16 | — | — | CN | claimed |
| CN-110023315-B | Novel compound or pharmacologically acceptable salt thereof | 国立研究开发法人理化学研究所 | 2021-11-12 | — | — | CN | claimed |
| US-11021493-B2 | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2021-06-01 | — | — | US | claimed |
| CN-103313973-B | N-benzyl heterocyclic carboxamide | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-09-16 | — | — | CN | claimed |
| CN-104507957-A | Hydroxystatin derivatives for treatment of arthrosis | MERCK PATENT GMBH | 2015-04-08 | — | — | CN | claimed |
| US-8394795-B2 | Pyrazole [3, 4-B] pyridine Raf inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-03-12 | — | — | US | claimed |
| EP-2265610-B1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-12-12 | — | — | EP | claimed |
| US-20110092479-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-04-21 | — | — | US | claimed |
| EP-2265610-A1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | claimed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | claimed |
| EP-1077972-A1 | 1-ALKYL-4-[(3-OXETANYL-)BENZOYL]-5-HYDROXYPYRAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES | Dow AgroSciences LLC (US) | 2001-02-28 | — | — | EP | claimed |
| US-6140271-A | 1-ETHYL-4-(2-METHYL-3-(3-OXETANYLOXY)-4-METHYLSULFONYLBENZOYL) -5-HYDROXYPYRAZOLE, FOR EXAMPLE AND BENZOIC ACID CHEMICAL INTERMEDIATES; POSTEMERGENCE HERBICIDES | DOW AGROSCIENCES LLC (US) | 2000-10-31 | — | — | US | claimed |
| WO-2000017194-A1 | 1-ALKYL-4-[(3-OXETANYL-)BENZOYL]-5-HYDROXYPYRAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2000-03-30 | — | — | WO | claimed |