Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17404655 | 0.86 | ALK (0.64) | ALKJAK2 | |
| SCHEMBL17310226 | 0.79 | ALK (0.77) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL15933007 | 0.78 | ALK (0.56) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL15932986 | 0.78 | ALK (1.00) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20590754 | 0.77 | ALK (0.78) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL15933001 | 0.76 | ALK (1.00) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL17310235 | 0.76 | ALK (0.72) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL17310117 | 0.75 | ALK (0.75) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL17310079 | 0.73 | JAK2 (0.50) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL17310163 | 0.70 | JAK2 (0.49) | ALKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952510-B1 | SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2018-12-26 | — | — | EP | disclosed |
| US-9708295-B2 | Substituted 2-aminopyridine protein kinase inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-07-18 | — | — | US | disclosed |
| EP-2952510-A1 | SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2015-12-09 | — | — | EP | disclosed |
| EP-2952510-A1 | SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014117718-A1 | SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR | 正大天晴药业集团股份有限公司 (CN) | 2014-08-07 | — | — | WO | disclosed |