Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947718 | 0.93 | DYRK1A (0.32) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL13105437 | 0.91 | DYRK1A (0.32) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL954626 | 0.86 | PIK3CA (0.42) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL954282 | 0.86 | PIK3CA (0.40) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL956193 | 0.86 | PIK3CA (0.40) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL12918084 | 0.85 | DYRK1A (0.31) | DYRK1AGSK3AGSK3BCLK4BACE1 | |
| SCHEMBL15935926 | 0.85 | PIK3CA (0.40) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL12918088 | 0.85 | PIK3CA (0.39) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL12947584 | 0.85 | PIK3CA (0.39) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL12947585 | 0.83 | MTOR (0.38) | DYRK1AGSK3AGSK3BCLK4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139589-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-8796314-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |