Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935946 | 0.91 | DYRK1A (0.40) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL13105952 | 0.87 | KDM4E (0.36) | PIK3CAMTOR | |
| SCHEMBL13105658 | 0.87 | PIK3CA (0.32) | PIK3CAMTOR | |
| SCHEMBL12947718 | 0.86 | DYRK1A (0.32) | DYRK1AGSK3AGSK3BCLK4PIK3CA | |
| SCHEMBL13105651 | 0.85 | MET (0.32) | PIK3CAMTORMAPTCYP3A4 | |
| SCHEMBL13105844 | 0.83 | PIK3CA (0.32) | PIK3CAMTOR | |
| SCHEMBL13105659 | 0.83 | TGFBR1 (0.38) | GSK3AGSK3BCYP3A4AAK1 | |
| SCHEMBL13105656 | 0.82 | CDK2 (0.33) | GSK3BPIK3CAMTORMAPT | |
| SCHEMBL13105654 | 0.82 | CNR1 (0.33) | GSK3BPIK3CAMTOR | |
| SCHEMBL13105849 | 0.82 | NR3C2 (0.37) | GSK3BPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256172-A1 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256172-A1 | Heteroaryls and uses thereof | PIK3R3, PIK3R1, AKT3 | DYRK1A 1006/4885GSK3A 26/4885GSK3B 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.