Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430176 | 0.96 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3226265 | 0.95 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL15947394 | 0.95 | SIGMAR1 (0.61) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL15939186 | 0.94 | SIGMAR1 (0.60) | SIGMAR1 | |
| SCHEMBL16352696 | 0.88 | SIGMAR1 (0.64) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL15940315 | 0.87 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL13430183 | 0.85 | SIGMAR1 (0.63) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL18816299 | 0.84 | SIGMAR1 (0.61) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL3228375 | 0.84 | SIGMAR1 (0.61) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL15939200 | 0.82 | SIGMAR1 (0.57) | SIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140228375-A1 | SIGMA RECEPTORS LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES, OVER CELLULAR MECHANISMS, EXHIBITING PROTOTYPICAL CYTOPROTECTIVE AND ALSO ANTI-CANCER ACTIVITY | ANAVEX LIFE SCIENCES CORP. (US) | 2014-08-14 | — | — | US | claimed |
| US-9180106-B2 | Sigma receptors ligands with anti-apoptotic and/or pro-apoptotic properties, over cellular mechanisms, exhibiting prototypical cytoprotective and also anti-cancer activity | ANAVEX LIFE SCIENCES CORP. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140228375-A1 | SIGMA RECEPTORS LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES, OVER CELLULAR MECHANISMS, EXHIBITING PROTOTYPICAL CYTOPROTECTIVE AND ALSO ANTI-CANCER ACTIVITY | ANAVEX LIFE SCIENCES CORP. (US) | 2014-08-14 | — | — | US | disclosed |