⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20843914 | 0.74 | — | — | |
| SCHEMBL13910099 | 0.72 | — | — | |
| SCHEMBL21737386 | 0.70 | — | — | |
| SCHEMBL22719968 | 0.70 | — | — | |
| SCHEMBL21720427 | 0.70 | — | — | |
| SCHEMBL16919281 | 0.70 | — | — | |
| SCHEMBL17236118 | 0.70 | PKM (0.44) | — | |
| Hydrochloric Acid SCHEMBL22834733 | 0.68 | — | — | |
| SCHEMBL21719950 | 0.67 | KDM4E (0.50) | — | |
| SCHEMBL21719452 | 0.67 | KDM4E (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956458-B1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2956458-B1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2956458-A1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | Pfizer Inc. (US) | 2015-12-23 | — | — | EP | disclosed |
| US-9192612-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9192612-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9192612-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150224110-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150224110-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150224110-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2015-08-13 | — | — | US | disclosed |
| US-9045499-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140364426-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364426-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER (US) | 2014-12-11 | — | — | US | disclosed |
| US-8865706-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865706-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865706-B2 | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2014125394-A1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014125394-A1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| US-20140228356-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140228356-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140228356-A1 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2014-08-14 | — | — | US | disclosed |