Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.69 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523629 | 0.82 | PIK3CG (1.00) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL15940389 | 0.77 | PIK3CG (0.58) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL2835239 | 0.77 | PIK3CG (0.64) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL15940392 | 0.74 | MAPT (0.55) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL15940355 | 0.73 | PIK3CG (0.47) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL4531912 | 0.71 | PIK3CG (0.81) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL15940390 | 0.70 | MEN1 (0.53) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5427675 | 0.68 | PIK3CG (1.00) | PIK3CGPI4KBMAPTHTTKDM4E | |
| SCHEMBL15940334 | 0.66 | MEN1 (0.55) | PIK3CGMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2840142 | 0.66 | PIK3CG (0.69) | PIK3CGPI4KBMAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | PIK3CG 2806/4885PI4KB 2458/4885MAPT 4151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.