PF4

Platelet factor 4 · P02776 · PF4 on Sugi Atlas →

392 patent compounds predicted against PF4, 332 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fondaparinux (SCHEMBL4937)	0.68	2/20
SCHEMBL31087042	0.60	2/20
SCHEMBL29386492	0.49	2/20
SCHEMBL29383445	0.48	2/20
SCHEMBL17167238	0.47	2/20
SCHEMBL17167232	0.47	2/20
SCHEMBL17167541	0.46	2/20
Fondaparinux (SCHEMBL1650579)	0.45	2/20
Fondaparinux (SCHEMBL14227800)	0.45	2/20
Fondaparinux (SCHEMBL15296579)	0.45	2/20
Fondaparinux (SCHEMBL17655218)	0.45	2/20
Fondaparinux (SCHEMBL19619397)	0.45	2/20
SCHEMBL17167223	0.43	2/20
SCHEMBL17167553	0.43	2/20
SCHEMBL29399207	0.42	2/20
SCHEMBL13431406	0.42	2/20
SCHEMBL17167254	0.42	2/20
SCHEMBL13431409	0.42	2/20
SCHEMBL13431418	0.42	2/20
SCHEMBL13431469	0.42	2/20

Clinical trials — most relevant to PF4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects	PHASE4	COMPLETED
Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor	PHASE4	RECRUITING
Nebulized Heparin in Severe Acute Respiratory Syndrome COVID-19	PHASE4	UNKNOWN
Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes	PHASE4	COMPLETED
Multicenter Trial of Antithrombotic Strategies in Acute Coronary Syndrome With Coronary Artery Ectasia	PHASE4	RECRUITING
Effect of Sublingual Immunotherapy on Platlet factor4 Level in Children	PHASE3	UNKNOWN
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy	PHASE3	NOT_YET_RECRUITING
Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction	PHASE2	COMPLETED
A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke	PHASE2	UNKNOWN
A Phase 2 Open Label Study to Assess the PK/PD Properties of RUC-4 in Patients With a ST-elevation Myocardial Infarction	PHASE2	COMPLETED
A Study To Assess The Safety Of PF-06342674 In Healthy Volunteers	PHASE1	COMPLETED
Risk of Developing Antibodies to Heparin-PF4 After Heart Surgery	nan	COMPLETED
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Optimizing the Diagnosis of Heparin Induced Thrombocytopenia	nan	UNKNOWN
Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical	nan	COMPLETED
Performance Evaluation of the Biological Diagnosis of HIT	nan	UNKNOWN
Platelet Rich Plasma for Uterine Scar	nan	RECRUITING
Pharmacogenomics of Heparin-Induced Thrombocytopenia	nan	RECRUITING
Immunogenetics of Heparin-Induced Thrombocytopenia: Aim 2	nan	COMPLETED
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling	nan	COMPLETED
Circulating Endothelial Compartment During Normal and Pathological Aging	nan	COMPLETED
Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study	nan	COMPLETED
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock	nan	COMPLETED
the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele	nan	COMPLETED
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects	nan	UNKNOWN
EMR Tool Impact on HIT Documentation and Management	nan	COMPLETED
Platelet Rich Plasma Versus Placebo for the Treatment of Greater Trochanteric Pain Syndrome (HiPPO Trial)	nan	COMPLETED
Platelets in Liver Regeneration	nan	UNKNOWN
Integrated Phenotyping of the Gut-plAtelet-Liver AXIS in the Progression of Chronic Liver Disease (iGAL-AXIS)	nan	NOT_YET_RECRUITING
Patient Satisfaction and Bone Gain Following Autogenous Particulate Sticky Bone Preparation With Xenograft Versus Without Xenograft for Grafting of Maxillary Anterior Knife Edge Ridge in Partially Edentulous Patients for Implant Placement	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PF4 binder may also engage these)

Protein	Name	Similarity
P10720	—	0.998	P10720 →
P06765	—	0.997	P06765 →
P43030	—	0.993	P43030 →
Q9Z126	—	0.991	Q9Z126 →
P30035	—	0.990	P30035 →
Q99731	—	0.986	Q99731 →
P36925	—	0.985	P36925 →
CXCL10	C-X-C motif chemokine 10	0.985	landscape →
P22952	—	0.984	P22952 →
Q9XSX5	—	0.984	Q9XSX5 →
P80162	—	0.984	P80162 →
P42830	—	0.984	P42830 →
P19874	—	0.983	P19874 →
P67813	—	0.982	P67813 →
P67814	—	0.982	P67814 →
P50228	—	0.981	P50228 →
Q2KIQ8	—	0.981	Q2KIQ8 →
P82943	—	0.981	P82943 →
O55038	—	0.980	O55038 →
Q8MIZ1	—	0.980	Q8MIZ1 →
Q6W5C0	—	0.980	Q6W5C0 →
P46653	—	0.979	P46653 →
Q7YRB5	—	0.979	Q7YRB5 →
P48973	—	0.979	P48973 →
Q102R3	—	0.979	Q102R3 →
P41324	—	0.979	P41324 →
P17515	—	0.978	P17515 →
P26894	—	0.978	P26894 →
P02775	—	0.978	P02775 →
P49113	—	0.978	P49113 →