Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.51 |
| ▸ | IL4I1 | Q96RQ9 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112336 | 0.91 | USP30 (0.49) | USP30IL4I1HDAC3HDAC4HDAC1 | |
| SCHEMBL3606179 | 0.90 | USP30 (0.52) | USP30HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12116814 | 0.86 | ACACB (0.55) | USP30 | |
| SCHEMBL1314099 | 0.86 | CACNA1I (0.58) | USP30HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1314432 | 0.86 | USP30 (0.54) | USP30HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1313591 | 0.86 | HDAC3 (0.55) | USP30HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12112674 | 0.85 | IL4I1 (0.50) | USP30IL4I1HDAC3HDAC4HDAC1 | |
| SCHEMBL1316537 | 0.84 | CACNA1I (0.54) | USP30HDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL1314946 | 0.84 | IL4I1 (0.49) | USP30IL4I1HDAC3HDAC4HDAC1 | |
| SCHEMBL1315256 | 0.84 | USP30 (0.47) | USP30HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375899-B1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF IN THE TREATMENT OF DIABETES | ARRAY BIOPHARMA INC (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8809538-B2 | Piperidine-containing compounds and use thereof | ARRAY BIOPHARMA INC. (US) | 2014-08-19 | — | — | US | disclosed |