Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | CTSA | P10619 | 10/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362685 | 0.93 | GPBAR1 (0.61) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365553 | 0.91 | GPBAR1 (0.47) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1389580 | 0.90 | GPBAR1 (0.68) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364591 | 0.90 | GPBAR1 (0.68) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364000 | 0.87 | GPBAR1 (0.57) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL362655 | 0.85 | GPBAR1 (0.61) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL362597 | 0.85 | GPBAR1 (0.54) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL369861 | 0.84 | GPBAR1 (0.55) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10291336 | 0.84 | GPBAR1 (0.59) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL371338 | 0.83 | GPBAR1 (0.55) | GPBAR1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |