Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.45 |
| ▸ | CTSA | P10619 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364671 | 0.92 | GPBAR1 (0.64) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL363421 | 0.89 | GPBAR1 (0.71) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1390018 | 0.89 | GPBAR1 (0.71) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364811 | 0.89 | GPBAR1 (0.59) | GPBAR1CTSANR3C2 | |
| SCHEMBL365553 | 0.89 | GPBAR1 (0.47) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364000 | 0.85 | GPBAR1 (0.57) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1390079 | 0.85 | GPBAR1 (0.53) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL362597 | 0.84 | GPBAR1 (0.54) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL362410 | 0.84 | GPBAR1 (0.56) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1390128 | 0.83 | MAPK1 (0.46) | GPBAR1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885PSEN1 663/4885PSEN2 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.