Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.70 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 5/20 | 0.37 |
| ▸ | ACACA | Q13085 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949337 | 0.90 | GPBAR1 (0.79) | GPBAR1PORCNROCK2ROCK1MEN1 | |
| SCHEMBL15949051 | 0.90 | GPBAR1 (0.79) | GPBAR1PORCNROCK2ROCK1MEN1 | |
| SCHEMBL15949249 | 0.90 | GPBAR1 (0.79) | GPBAR1PORCNROCK2ROCK1MEN1 | |
| SCHEMBL15949282 | 0.90 | GPBAR1 (0.79) | GPBAR1PORCNROCK2ROCK1MEN1 | |
| SCHEMBL15949232 | 0.90 | GPBAR1 (0.79) | GPBAR1PORCNROCK2ROCK1MEN1 | |
| SCHEMBL1390359 | 0.88 | GPBAR1 (0.77) | GPBAR1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL10241002 | 0.88 | GPBAR1 (0.77) | GPBAR1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL15949323 | 0.88 | GPBAR1 (0.77) | GPBAR1PORCNROCK2ROCK1CTSA | |
| SCHEMBL15949236 | 0.85 | GPBAR1 (0.69) | GPBAR1PORCNROCK2ROCK1CTSA | |
| SCHEMBL15949226 | 0.83 | GPBAR1 (0.74) | GPBAR1PORCNROCK2ROCK1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |