Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PRKX | P51817 | 2/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10241002 | 1.00 | GPBAR1 (0.77) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL10240995 | 0.91 | GPBAR1 (0.77) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL1390099 | 0.91 | GPBAR1 (0.77) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL362477 | 0.91 | GPBAR1 (0.77) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL1390098 | 0.91 | GPBAR1 (0.77) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL1390103 | 0.89 | GPBAR1 (0.60) | GPBAR1ROCK1ROCK2PRKACAPRKG1 | |
| SCHEMBL15949185 | 0.88 | GPBAR1 (0.70) | GPBAR1ROCK1ROCK2MEN1KMT2A | |
| SCHEMBL364196 | 0.87 | GPBAR1 (1.00) | GPBAR1CTSA | |
| SCHEMBL362606 | 0.87 | GPBAR1 (1.00) | GPBAR1CTSA | |
| SCHEMBL364261 | 0.87 | GPBAR1 (1.00) | GPBAR1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885ROCK1 3390/4885ROCK2 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.