Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389850 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1390613 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1390568 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL370163 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1389856 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL370166 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1390234 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1389852 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL370165 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 | |
| SCHEMBL1390235 | 0.90 | GPBAR1 (0.51) | GPBAR1APAF1MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |