Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949047 | 0.90 | GPBAR1 (0.59) | GPBAR1FFAR1CYP17A1ABHD6ROCK2 | |
| SCHEMBL1389885 | 0.85 | GPBAR1 (0.58) | GPBAR1FFAR1CYP17A1RXRARXRB | |
| SCHEMBL362229 | 0.85 | GPBAR1 (0.58) | GPBAR1FFAR1CYP17A1RXRARXRB | |
| SCHEMBL1389571 | 0.83 | GPBAR1 (0.49) | GPBAR1FFAR1CYP17A1RXRARXRB | |
| SCHEMBL363233 | 0.83 | GPBAR1 (0.49) | GPBAR1FFAR1CYP17A1RXRARXRB | |
| SCHEMBL363331 | 0.82 | GPBAR1 (0.55) | GPBAR1CYP17A1ROCK2 | |
| SCHEMBL1390313 | 0.82 | GPBAR1 (0.55) | GPBAR1CYP17A1ROCK2 | |
| SCHEMBL15949226 | 0.81 | GPBAR1 (0.74) | GPBAR1FFAR1RXRARXRBCTSA | |
| SCHEMBL363119 | 0.81 | GPBAR1 (0.64) | GPBAR1RXRARXRBROCK2RPS6KA5 | |
| SCHEMBL1389878 | 0.81 | GPBAR1 (0.64) | GPBAR1RXRARXRBROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |