SCHEMBL15949239

SCHEMBL15949239

c1cnnc(C2COCCN2)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 1/20 0.38
CSNK1E P49674 1/20 0.38
KCNH2 Q12809 1/20 0.38
PRKACA P17612 1/20 0.38
PRKACG P22612 1/20 0.38
PRKACB P22694 1/20 0.38
CHRNB2 P17787 4/20 0.35
CHRNA4 P43681 4/20 0.35
CHRNA7 P36544 2/20 0.35
MEN1 O00255 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C19 P33261 2/20 0.34
KMT2A Q03164 2/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2A6 P11509 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15949228 0.79 CSNK1D (0.44) CSNK1DCSNK1EKCNH2PRKACAPRKACG
SCHEMBL137900 0.75 CHRNB2 (0.59) PRKACAPRKACGPRKACBCHRNB2CHRNA4
SCHEMBL30240863 0.75 CHRNB2 (0.59) PRKACAPRKACGPRKACBCHRNB2CHRNA4
SCHEMBL6840406 0.75
SCHEMBL24540890 0.74 CSNK1D (0.36) CSNK1DCSNK1EKCNH2PRKACAPRKACG
Hydrochloric Acid SCHEMBL31227410 0.74 CHRNB2 (0.57) PRKACAPRKACGPRKACBCHRNB2CHRNA4
SCHEMBL28374430 0.73 CHRNB2 (0.54) CHRNB2CHRNA4CHRNA7MEN1CYP2D6
SCHEMBL28029556 0.72 PRKACA (0.36) CSNK1DCSNK1EKCNH2PRKACAPRKACG
SCHEMBL24540654 0.72 CSNK1D (0.37) CSNK1DCSNK1EKCNH2PRKACAPRKACG
SCHEMBL1333528 0.72 PRKACA (0.49) CSNK1DCSNK1EKCNH2PRKACAPRKACG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2057133-B1 DI-AMINO-SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC (US) 2014-08-20 EP disclosed